|
Progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy-like syndrome
|
0.540 |
GermlineCausalMutation
|
disease |
ORPHANET |
CCDC88A mutations cause PEHO-like syndrome in humans and mouse.
|
26917597 |
2016 |
|
Neoplasm Metastasis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Subsequent work has revealed that expression of the highly specialized C-terminus of GIV undergoes a bipartite dysregulation during oncogenesis-full length GIV with an intact C-terminus is expressed at levels ~20-50-fold above normal in highly invasive cancer cells and metastatic tumors, but its C-terminus is truncated by alternative splicing in poorly invasive cancer cells and non-invasive tumors.
|
21546796 |
2011 |
|
Neoplasm Metastasis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Here we report the discovery that GIV is a direct target of the transcription factor signal transducer and activator of transcription-3 (STAT3), which is commonly known as a central regulator of tumor metastasis.
|
23066027 |
2012 |
|
Neoplasm Metastasis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of Girdin protein was related to histological grade and distant metastasis (P = 0.007 and 0.007, respectively).
|
22714912 |
2012 |
|
Neoplasm Metastasis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
GIV expression promotes metastasis and disruption of its binding to Gαi blunts the pro-metastatic behavior of cancer cells.
|
28819150 |
2017 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In our previous studies, we firstly found Girdin protein was overexpressed in HCC tissues, and it closely correlated to tumor size, T stage, TNM stage and Edmondson-Steiner stage of HCC patients.
|
26743900 |
2016 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Subsequent work has revealed that expression of the highly specialized C-terminus of GIV undergoes a bipartite dysregulation during oncogenesis-full length GIV with an intact C-terminus is expressed at levels ~20-50-fold above normal in highly invasive cancer cells and metastatic tumors, but its C-terminus is truncated by alternative splicing in poorly invasive cancer cells and non-invasive tumors.
|
21546796 |
2011 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Real-time PCR expression profile depicts that mature form of both miRNAs is significantly overexpressed in low-grade (GII) tumor tissue samples compared to control and high-grade (GIII and GIV) tissue samples.
|
27900675 |
2017 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Since APE/Ref-1 expression level and intracellular localization is variable in different types of tumors and frequently found to be different in non-malignant compared to the corresponding malignant human tissue, the protein is thought to be a diagnostic and prognostic tumor marker.
|
14599768 |
2003 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Kaplan-Meier analysis of disease-free survival in cancer patients shows poor prognosis for patients with high expression of both GIV and GRP78, further suggesting a vital role for these two proteins in enhancing cancer cell viability.
|
31736058 |
2020 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Kaplan-Meier analysis of disease-free survival in cancer patients shows poor prognosis for patients with high expression of both GIV and GRP78, further suggesting a vital role for these two proteins in enhancing cancer cell viability.
|
31736058 |
2020 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
We identified a single STAT3-binding site on the GIV promoter that was necessary and sufficient for transcriptional activation of GIV during wound healing and cancer invasion.
|
23066027 |
2012 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Introduction of STAT3 overexpression restored the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells.
|
27998773 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, the present study suggested that girdin protein expression was significantly correlated with cancer progression and poor prognosis in ESCCs, and that girdin had a positive role in the regulation of cell proliferation, migration and invasion in ESCC cells.
|
24865549 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunoblotting showed that APE/Ref-1 protein levels are increased in selectively vulnerable central nervous system (CNS) regions in individuals with ALS compared to age-matched controls.
|
12230304 |
2002 |
|
Tumor Progression
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, the present study suggested that girdin protein expression was significantly correlated with cancer progression and poor prognosis in ESCCs, and that girdin had a positive role in the regulation of cell proliferation, migration and invasion in ESCC cells.
|
24865549 |
2014 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
APE/Ref-1 was upregulated in HCC cells consistent with the strong expression of APE/Ref-1 in HCC tissue microarray.
|
25109342 |
2014 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.
|
20974669 |
2011 |
|
Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using an immunohistochemical method, fixed tissue from 31 newly diagnosed pediatric rhabdomyosarcomas were evaluated for expression of APE/ref1.
|
11846302 |
2001 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After analyzing survival rates, cases with highly expressed Girdin protein were shown to attain a significantly higher rate of liver metastasis and poorer postoperative, disease-specific survival than those with no or low expressed Girdin protein (P = 0.001).
|
22714912 |
2012 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis of breast carcinomas showed significant correlation between STAT3 activation and elevated GIV expression.
|
23066027 |
2012 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.
|
20974669 |
2011 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we report the discovery that GIV is a direct target of the transcription factor signal transducer and activator of transcription-3 (STAT3), which is commonly known as a central regulator of tumor metastasis.
|
23066027 |
2012 |
|
Motor neuron atrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated whether motor neuron degeneration in ALS is associated with changes in the levels and function of the multifunctional protein apurinic/apyrimidinic endonuclease (APE/Ref-1).
|
12230304 |
2002 |
|
Progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy-like syndrome
|
0.540 |
Biomarker
|
disease |
BEFREE |
We suggest that PEHO or a PEHO-like syndrome may affect more patients than are currently identified, based on the original diagnostic criteria for this disorder.
|
12949965 |
2003 |